Inclusion Criteria

Inclusion Criteria

Concurrent Medication:

Allowed:

- Immunostimulants under studies carried out under an IRB approved protocol.

- Treatments of intercurrent non-fungal infection.

- Allowed but requires monitoring during fluconazole therapy:

- Barbiturates.

- Phenytoin.

- Oral hypoglycemics.

- Coumarin-type anticoagulants.

Patients must have the following:

- Diagnosis or presumption of fungal infection under defined conditions.

- Written informed consent either from the patient or the patient's legal guardian.

Exclusion Criteria

Co-existing Condition:

Patients with the following conditions or symptoms are excluded:

- Burns > 30 percent of the body.

- Diagnosis of AIDS or AIDS related complex (ARC).

- HIV positive unless they have a malignancy.

- History of allergy to or intolerance of imidazoles or azoles.

- Moderate to severe liver disease as defined by specific lab values.

- Unlikely to survive more than 24 hours.

- Evidence of previous amphotericin B sensitivity.

Concurrent Medication:

Excluded:

- Concomitant antifungal agents other than the study drugs.

- Immunostimulants, except for studies carried out under an IRB approved protocol.

Concurrent Treatment:

Excluded:

- Lymphocyte replacements.

Patients with the following are excluded:

- Defined disease conditions listed in Exclusion Co-Existing Conditions.

- Unlikely to survive more than 24 hours.

- Previous participation in this study; reentry for the same infection is not allowed.

- Known to be unable to take amphotericin B due to acute toxicities.

Prior Medication:

Excluded:

- Previous fluconazole therapy for this infection.