Trial Information

Evaluation and Treatment of Subjects With Dermatologic Diseases

Background

This is a training, natural history of disease, and screening protocol for the evaluation,
treatment and follow-up of patients with dermatologic diseases and systemic diseases with
cutaneous manifestations. This protocol was developed to allow subject enrollment for
teaching purposes and to allow for second opinions regarding relatively complicated
patients. The latter function promotes a critical link between the NCI, CCR Dermatology
Branch and the local and national extramural medical communities.

Objective

Primary:

- To provide clinical material to fulfill the educational mission of the

Dermatology Branch.

- To learn about the natural history of selected dermatologic diseases.

Secondary:

- To screen patients for inclusion in other protocols.

- To assist in the diagnosis and/or management of patients with rare skin diseases and
congenital or genetically linked skin conditions.

Eligibility

All subjects regardless of age, gender, or racial/ethnic group with dermatologic disease or
systemic disease with cutaneous manifestations.

Design

Patients enrolled in this protocol will be evaluated and treated according to generally
available, standard procedures and therapeutic modalities. Samples of blood and skin will be
studied by routine and specialized investigative methods to establish these patients'
diagnosis, response to treatment, and/or disease progression.