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Genetic Analysis of Hereditary Prostate Cancer

18 Years
Not Enrolling
Hereditary Neoplastic Syndrome, Prostatic Neoplasm

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Trial Information

Genetic Analysis of Hereditary Prostate Cancer

Molecular approaches to the understanding of human neoplastic disease have revealed that
multiple genetic alterations are an essential component of tumorigenesis. Both germline and
somatic genetic alterations can be involved in the malignant transformation of normal cells.
Identification of the genes involved in neoplastic transformation has been approached
through the molecular analysis of sporadic cancers and the genetic study of families with an
inherited predisposition for cancer. The interplay of these two approaches has led to the
characterization of genes such as the retinoblastoma (Rb) gene, the p53 gene and the
adenomatous polyposis coli (APC) gene that are all involved in the development of both
hereditary and non-hereditary forms of cancer. Inherited mutations in such genes predispose
affected families to hereditary cancer syndromes, affording an opportunity to identify
genetic lesions that also cause the more common sporadic cancers.

Prostate cancer (PRCA) is the most common cancer diagnosed (1999 estimate 179,300 cases) and
the second leading cause of cancer mortality (1999 estimate 37,000 deaths) in men in the
United States. Family history is the single strongest risk factor currently known for
prostate cancer. This raises the possibility that heritable genetic factors may be involved
in the development of this disease in a subset of men. The genetic contribution to diseases
of complex origin such as cancer is often most salient in families of early onset cases.
Therefore, prostate cancer inheritance following a simple Mendelian pattern may be
identified in the families of probands with early-onset cases. Common susceptibility
alleles of small effect may be detectable in families with later-onsent and/or less strong
family history of PRCA or in case-control data.

Inclusion Criteria


Enrollment in this study includes case-control data from men with prostate cancer and
matched controls who are free from the disease, plus affected and unaffected individuals
from families who meet the following criteria for Hereditary Prostate Cancer:

1. A cluster of 3 or more first degree relatives, such as a father and 2 sons or 3

2. The occurrence of prostate cancer in each of 3 generations in either the proband's
paternal or maternal lineages

3. Two first or second-degree relatives affected at an early age (age 55 years or

Type of Study:


Study Design:


Principal Investigator

Joan Bailey-Wilson, Ph.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

National Human Genome Research Institute (NHGRI)


United States: Federal Government

Study ID:




Start Date:

July 1995

Completion Date:

Related Keywords:

  • Hereditary Neoplastic Syndrome
  • Prostatic Neoplasm
  • Genotyping
  • Linkage Analysis
  • Adenocarcinoma
  • Micro Satellite
  • Hereditary
  • Prostate Cancer (hereditary)
  • Neoplasms
  • Neoplastic Syndromes, Hereditary
  • Prostatic Neoplasms



Albert Einstein College of Medicine Bronx, New York  10461
National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland  20892
Translational Genomics Research Institute Phoenix, Arizona  
Howard University Hospital Washington, District of Columbia  20060
Louisiana State University New Orleans, Louisiana  70112-2282
Johns Hopkins University Baltimore, Maryland  21205
Wake Forest University Winston-Salem, North Carolina  27103