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Outcomes of Education and Counseling for BRCA1 or BRCA2 Testing

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Breast Neoplasms, Ovarian Neoplasms

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Trial Information

Outcomes of Education and Counseling for BRCA1 or BRCA2 Testing

Women at increased risk for developing breast and/or ovarian cancer and their first degree
relatives will be offered BRCA1/2 gene testing. This study proposes to evaluate
psychological and behavioral aspects of their decision-making and the outcomes of the
testing process. Knowledge and expectations will be assessed initially, followed by
pre-test psychological assessment and an in person education and counseling session.
Participants will be presented the choice of whether or not to undergo BRCA1/2 testing.
Notification of test results will occur in person along with discussion of available
surveillance options. Telephone interviews will assess psychological and behavioral outcome
measures at 6 and/or twelve month time points. Aspects of this research endeavor have been
designed to complement an NHGRI/NCI extramural consortium and an NHGRI/NCI intramural
collaboration both of which will address various aspects of risk notification and follow-up
for hereditary breast, ovarian and colon cancer.

Inclusion Criteria

Participants will be drawn from the families enrolled by Drs. Peggy Tucker and Jeff
Struewing in the GEB of NCI (protocol 78-C-0039).

Individual with a family history of verified breast and/or ovarian cancer that includes;

1. two cases of ovarian cancer in first degree relatives, or

2. three cases of breast cancer and at least one case of ovarian cancer (two of which
have to be first degree relatives), or

3. at least four cases of breast cancer.

Type of Study:


Study Design:



United States: Federal Government

Study ID:




Start Date:

March 1995

Completion Date:

February 2001

Related Keywords:

  • Breast Neoplasms
  • Ovarian Neoplasms
  • Behavioral and Attitudinal Changes
  • Breast Cancer
  • High Risk Families
  • Inherited Susceptibility
  • Psychological Responses to Risk
  • Breast Neoplasms
  • Neoplasms
  • Ovarian Neoplasms



National Human Genome Research Institute (NHGRI) Bethesda, Maryland  20892