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Immunopathology and Molecular Pathology of Ocular Diseases in Humans

Open (Enrolling)
Conjunctival Disease, Corneal Disease, Eye Disease, Uveitis, Vitreoretinopathy, Proliferative

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Trial Information

Immunopathology and Molecular Pathology of Ocular Diseases in Humans

The purpose of this project is to diagnose and evaluate ocular and related tissues with
various diseases such as conjunctival, corneal, uveal, vitreoretinal, scleral and optic
nerve disorders, ocular degenerative, inflammatory, metabolic or genetic diseases and
tumors. These will be studied using light microscopy, electron microscopy, confocal
microscopy, immunohistochemistry, molecular pathology including microdissection and
polymerase chain reaction and in situ hybridization, as well as measuring the functions of
cellular organelles, e.g., mitochondrial function. Lymphocytes in the peripheral blood,
serum, as well as other involved biopsied tissues and ocular tissue will be compared and
categorized by disease and normal. Cytokines, chemokines, growth factors, antibodies, and/or
other released molecules in the blood, CNF, and ocular fluids will be also analyzed. We will
compare the tissue morphology as well as immunological and biochemical indexes, e.g.,
cytokine/chemokine levels, growth factors and antibodies between the diseases and normals.
Elucidating the relationship between the infiltrating cells, ocular resident cells, and
their products in various diseases will help us to make diagnoses and increase our
understanding of human ocular disorders.

Inclusion Criteria


1. Participants must be undergoing an eye procedure for clinical care of their
condition which requires the removal of tissue specimens or have agreed
pre-mortem to donate their eyes after death for research purposes.

2. Participants must agree to the de-identified storage of their sample for
potential use in future research projects.

3. For conditions where blood is needed for analysis, participants must consent to
having blood drawn for research evaluation, and be able to safely give a blood

4. Participants must be able to give informed consent for themselves and/or their
minor children who wish to enroll.


1. Participant is unwilling or unable to give informed consent.

Type of Study:


Study Design:


Principal Investigator

Chi-Chao Chan, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

National Eye Institute (NEI)


United States: Federal Government

Study ID:




Start Date:

March 1992

Completion Date:

Related Keywords:

  • Conjunctival Disease
  • Corneal Disease
  • Eye Disease
  • Uveitis
  • Vitreoretinopathy, Proliferative
  • Ocular Pathology
  • Ocular Immunology
  • Clinicopathological Correlation
  • Immunohistochemical Methods
  • In Situ Hybridization
  • Polymerase Chain Reaction
  • Microdissection
  • Ocular Disease
  • Conjunctival Diseases
  • Corneal Diseases
  • Eye Diseases
  • Uveitis
  • Chorioretinitis
  • Vitreoretinopathy, Proliferative



National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland  20892