Inclusion Criteria

Inclusion Criteria

Patients who have a primary diagnosis of AIDS related complex (ARC) including
lymphadenopathy syndrome (LAS), who are positive for HIV antibody, have a minimum life
expectancy of 3 months, and have one or more of the following symptoms for = or > 30 days:

- Fever.

- Night sweats.

- Fatigue.

- Oral thrush.

- Hairy leukoplakia.

- Diarrhea.

- Weight loss < 10 percent.

- Patients must be able to sign a written informed consent form, which must be obtained
prior to treatment.

Concurrent Medication:

Allowed:

- Acetaminophen for temperature rise of > 38.5 degrees C - 650 mg by mouth every 4
hours on an as needed basis.

Severe rigors may be treated (or prevented) with meperidine 50 mg IV on an as needed basis
in the absence of systolic hypotension < 80 mm Hg.

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Exclusion Criteria

Co-existing Condition:

Patients with the following are excluded:

- Clinically significant cardiac disease - New York Heart Association Class II, III, or
IV.

- Hemorrhagic diathesis (including hemophilia) or active bleeding disorder (e.g.,
genitourinary, gastrointestinal).

- Clinically apparent vascular disease (including a prior history of pulmonary embolus,
deep venous thrombosis, or peripheral arterial occlusive disease).

Concurrent Medication:

Excluded:

- Medications required for the treatment of active cardiac disease including cardiac
glycosides, antiarrhythmics and antianginal agents.

- Anticoagulants.

- Thrombolytic agents.

- Nonsteroidal anti-inflammatory drugs.

- Ongoing therapy with vasodilators.

- Aspirin.

- Corticosteroids.

- Antihistamines.

- Barbiturates.

- Excluded within 4 weeks of study entry:

- Antiviral chemotherapy.

- Immunotherapy.

- Excluded within 12 weeks of study entry:

- Suramin.

Patients with the following are excluded:

- AIDS-associated opportunistic infection.

- Lipoprotein disorders.

- Hemophilia.

Prior Medication:

Excluded:

- Interferon gamma.

- Tumor necrosis factor.