The Case Comprehensive Cancer Center (Case CCC) based at Case Western Reserve University (CWRU) is a partnership organization supporting all cancer-related research efforts at CWRU, University Hospitals Case Medical Center, and Cleveland Clinic, and MetroHealth Medical Center. Located in Cleveland, Ohio, the Case CCC serves the cancer research and clinical needs of an urban manufacturing and rural agricultural region containing 3.8 million people in Northern Ohio. The Case CCC provides a unique forum and academic network for cancer researchers across our community to accomplish more than they may individually. Through the Case CCC, our medical institutions are linked in a stronger and more unified effort to understand the causes and progression of cancer and to use that understanding to develop treatments and to reduce the likelihood that our population will develop cancer and suffer from its consequences. The Cancer Center advocates for cancer research support across the institutions; provides funding for promising pilot grants, shared resource development, training programs, and recruitments; and catalyzes multidisciplinary and transdisciplinary cancer research across institutions, emphasizing innovative discovery that will have an impact on cancer patients.