Inclusion Criteria:

- Patients who are pathologically/cytologically diagnosed as NSCLC and received
radiotherapy with or without chemotherapy, and the last radio- or chemo-therapy must
be at least 30 days prior to initiation of experimental treatment;

- Participants who meet the diagnosis criteria of CRF（ICD-10 criteria);

- The first time to receive acupuncture treatment;

- The age is between 18 and 65 years old;

- Mean baseline fatigue as measured by the Brief Fatigue Inventory (BFI) must be four
or above;

- ECOG performance status 0, 1 or 2.

- Patients must have adequate organ functions reflected by the laboratory criteria
below: neutrophil counts ≥ 1.5×109 /L, platelet count ≥ 100 x 109/L, hemoglobin ≥ 85
g/L, Serum creatinine < 2.0 mg/dL, Bilirubin < 1.5 mg/dL, ALT < 3 x normal, albumin
>30g/L.

- Have not taken any hypnotic, melatonin, or antidepressants within 30 days;

- Willing to finish the whole observation period;

- With written consent form signed by themselves.

Exclusion Criteria:

- Participants in other clinical research;

- Can not be pathologically or cytologically diagnosed as NSCLC;

- ECOG 3~4;

- Pregnant woman;

- >65 or <18 years old;

- Patients with evidence of any cognitive dysfunction that would limit their abilities
to report fatigue;

- Patients who have received acupuncture ever before;

- Received surgery, immunotherapy or target therapy within one month before the
recruition；

- Taking warfarin or heparin, a bleeding tendency exists;

- Infection, ulceration or hyperalgesia at or near the local acupoints' skin，or with
active infections；

- There are cerebral vascular accident history or spinal cord injury history；

- Combination with other serious diseases or condition, including congestive heart
failure, Unstable angina pectoris, myocardial infarction during the past six months,
serious's arrhythmia, mental disorders, drug abuse, etc.;

- Patients with a life expectancy < 3 months;

- Patients with a past history of therapy or scheduled visits non-compliance, as
determined by their treating physician.