Research Evaluation of PET/MR and PET/CT Imaging for Bone Marrow Lesions
Imaging of the pelvis and bilateral femora at 1.5 Tesla in a 30 minute research time "slots"
at NYU-FPO MRI, Tisch Hospital, NYU Medical Center, Department of Radiology, HCC basement.
This protocol utilizes routine, Dixon sequences and multi-echo MR "spectroscopic" sequences,
allowing quantization of the fat water and trabecular moieties of marrow. The opposed phase
portion of a Dixon sequence can aid differentiation between dense red marrow and a
metastatic deposits by assaying for intravoxel fat. Diffusion sequences may also
potentially improve specificity by assessing mobility of water in hypercellular and
hypocellular portions of marrow, and will be added to the protocol if scan time permits.
The new sequences conform to FDA safety regulations regarding static magnetic field, time
varying magnetic fields, specific absorption rate, and acoustic noise levels. However, since
they have not been fully validated for diagnostic accuracy, the resulting images will be
analyzed for research purposes only and will not be used in the patient's diagnostic
Observational Model: Case-Only, Time Perspective: Prospective
To Improve specificity of Multiple Myeloma using PET MR
WHOLE BODY MRI/PET imaging for global assessment of the marrow in patients with MM. This will determine the feasibility of a multiple gradient echo sequence for differentiation of water and fat constituents of marrow, combined with T2* mapping to interrogate the trabecular component which would allow for increased identification of lesion type than routine MR Sequences, and can be used to quantitatively characterize myelomatous marrow replacement with the current biopsy as gold standard.
Sandra L Moore, MD
NYU School of Medicine
United States: Institutional Review Board
|NYU Center for Biomedical Imaging||New York, New York 10016|