Inclusion Criteria:

- Female, over 18 and under 80 years

- Diagnosis of breast cancer established (Pathology)

- Life expectancy greater than 6 months

- Surgery of breast lumpectomy with or without lymph node dissection, mastectomy with
or without lymph node dissection, dissection isolated

- ASA 1 (healthy patient) or 2 (patient with moderate to high function) according to
the classification of the American Society of Anesthesiologist,

- Affiliation to a social security scheme,

- Information on the study, signed informed consent

Exclusion Criteria:

- Presence of major psychiatric disorders or psychotic behavior addiction, evaluated by
neuropsychologist at the first preoperative consultation, through the test MINI
(MINI> 4 positive responses for each module)

- Presence of neurological disorders known untreated or evaluated by neuropsychologist
at the first preoperative consultation, with the MMSE test (MMSE <24)

- Patient treated morphine orally for 3 months or more

- Patient is pregnant or nursing, or of childbearing potential and not using adequate
contraception,

- Patient included in another clinical study

- Inability to undergo medical monitoring study for geographical, social or
psychological

- Patient deprived of liberty and most subject to a measure of legal protection or
unable to consent