Genetic Epidemiology of Ewing's Sarcoma
PRIMARY OBJECTIVES: I. To determine the association between the length of Ewing sarcoma
breakpoint region 1-Friend leukemia virus integration 1 (EWS-FLI1) fusion protein binding
sites (microsatellites) and risk of Ewing's sarcoma (ES). II. To determine the frequency
and commonality of Caucasian ancestral markers in cases of ES self-identified as
non-Caucasian (African-American, Asian, Hispanic). III. To determine the association
between genomic variants in ES-related genes and hernia development (i.e. the integrin
signaling pathway) and risk of ES. OUTLINE: Genomic DNA is extracted from participants'
saliva samples and analyzed for expression of EWS-FLI1 and other ES-target genes.
Time Perspective: Prospective
Main effect of gene polymorphisms
Risk ratios (RR) for the main effect of gene polymorphisms will be calculated using log-linear models. RRs and 95% confidence intervals for the gene-environment interaction are calculated by stratifying the likelihood according to case exposure.
Up to 5 years
Children's Oncology Group
United States: Institutional Review Board
|Children's Oncology Group||Arcadia, California 91006-3776|