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Reflectance Confocal Microscopy of Wounds During Moh's Surgery: Feasibility Testing of a Mosaicing Algorithm for Intraoperative Imaging of Cancer Margins


N/A
18 Years
N/A
Open (Enrolling)
Both
Basal Cell Carcinoma

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Trial Information

Reflectance Confocal Microscopy of Wounds During Moh's Surgery: Feasibility Testing of a Mosaicing Algorithm for Intraoperative Imaging of Cancer Margins


Inclusion Criteria:



- Patients undergoing Mohs surgery for basal cell carcinoma (BCC).

- Ability to sign informed consent.

- Age ≥ 18 years.

Exclusion Criteria:

- Mohs surgery located on a site that may not be convenient to confocal imaging.

- Inability to give informed consent.

- Inability to tolerate imaging procedure (i.e., remain relatively still for multiple
short durations of 3-4 minutes) over a total time of 20 minutes.

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

test feasibility of a mosaicing algorithm

Outcome Description:

For the primary study objective, the Mohs surgeon will perform a qualitative assessment of the confocal mosaic. This will be a dichotomous assessment of whether the mosaic is of sufficient quality (contrast and resolution) to identify individual features. The specific features for BCC margins are tumor nests with nuclear atypia and increased nuclear density (relative to the density seen in normal basal cells).

Outcome Time Frame:

1 year

Safety Issue:

No

Principal Investigator

Kishwer Nehal, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center

Authority:

United States: Institutional Review Board

Study ID:

12-239

NCT ID:

NCT01872130

Start Date:

May 2013

Completion Date:

May 2015

Related Keywords:

  • Basal Cell Carcinoma
  • Moh's Surgery
  • mosaicing algorithm
  • intraoperative imaging
  • 12-239
  • Carcinoma
  • Carcinoma, Basal Cell

Name

Location

Memorial Sloan Kettering Cancer CenterNew York, New York  10021
Memorial Sloan-Kettering at Basking RidgeBasking Ridge, New Jersey  07920
Memorial Sloan-Kettering at Mercy Medical CenterRockville Centre, New York