Inclusion Criteria:

- Female patient between the ages of 18 and 45 years

- Previously cryopreserved and stored cortical ovarian tissue available for autologous
transplantation

- Ovarian insufficiency defined as an elevated FSH over 10

- Inability to conceive after 6 months of unprotected intercourse with male

- Reasonably good health

- Candidate for pregnancy

- Written clearance for the procedure from the patients oncologist

Exclusion Criteria:

- Patients considered to be high risk for surgical complications will be excluded from
the research protocol

- Women who are known to be positive for the BRCA mutation

- Women with a history of leukemia, ovarian cancer or a cancer that likely involved the
ovaries at the time of ovarian tissue collection

- Women with psychological, psychiatric, or other conditions which prevent giving fully
informed consent

- Current pregnancy