Inclusion Criteria:

1. Patients must have histologically or cytologically confirmed adenocarcinoma of the
exocrine pancreas.

2. Patients must have locally advanced pancreatic cancer (LAPC).

3. Patients must have LAPC evaluated by radiologist and/or surgeon according to either
abdominal CT or MRI, or intra-operative findings.

- Locally advanced unresectable disease was defined by CT or MRI images as
low-density tumor (primary and/or lymphadenopathy) with

1. extension to the celiac axis or superior mesenteric artery,

2. occlusion of the superior mesenteric-portal venous confluence

3. aortic, inferior vena cava (IVC) invasion or encasement

4. invasion of SMV below transverse mesocolon or unresectable after surgical
exploration.

Those who had superior mesenteric vein impingement, superior mesenteric artery
abutment were defined as borderline resectable.

Those who had superior mesenteric vein occlusion, superior mesenteric artery
encasement were defined as unresectable.

4. Patients must have measurable disease, defined as at least one lesion that can be
accurately measured in at least one dimension (longest diameter to be recorded) as
>20 mm with conventional techniques or as >10 mm with spiral CT scan. See section 8.2
for the evaluation of measurable disease.

5. Age >20 years and ≦70 years.

6. ECOG performance score of 0 or 1; see Appendix A.

7. Patients must have normal organ and marrow function as defined below:

- absolute neutrophil count >1,500/mL

- platelets >100,000/mL

- total bilirubin <1.5X institutional upper limit of normal

- ALT(SGPT) <5 X institutional upper limit of normal

- creatinine within normal institutional limits or creatinine clearance>60
mL/min/1.73 m2 for patients with creatinine levels above institutional normal

8. Patients who present with jaundice will be allowed to enroll after control with
temporary or permanent internal/external drainage.

9. The effects of study agents on the developing human fetus at the recommended
therapeutic dose are unknown. Women of child-bearing potential and men must agree to
use adequate contraception (hormonal or barrier method of birth control; abstinence)
prior to study entry and for the duration of study participation. Should a woman
become pregnant or suspect she is pregnant while participating in this study, she
should inform her treating physician immediately.

10. Ability to understand and the willingness to sign a written informed consent
document.

Exclusion Criteria:

1. Patients with distant metastases are not eligible.

2. Patients with endocrine or acinar pancreatic carcinoma.

3. Patients may be receiving any steroid, immunologic or other investigational agents
within 4 weeks prior to enrollment.

4. Patients who have had prior chemotherapy or radiotherapy are not eligible.

5. History of allergic reactions attributed to compounds of similar chemical or biologic
composition to study agents used in the study.

6. Patients who have above grade II peripheral neuropathy.

7. Patients who had non-curable second primary malignancy within five years, except for
non-melanoma skin cancer.

8. Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements.

9. Pregnant women are excluded from this study because the study agents has the
potential for teratogenic or abortifacient effects. Because there is an unknown but
potential risk for adverse events in nursing infants secondary to treatment of the
mother with study agents, breastfeeding should be discontinued if the mother is
treated with the study agents.

10. Those who are immuno-compromised or receiving immuno-suppressive therapy are excluded
from the study because of increased risk of lethal infections and possible
pharmacokinetic interactions with study agent administered during the study.

11. Those who have chronic diarrhea.