Inclusion Criteria:

- Age greater than or equal to 70 years

- patient enrolled in ELAN-ONVOCAL study and evaluated as fit (harmonious aging) by
GERICO screening method for geriatric frailty

- life expectancy superior to 12 weeks

- creatinin clearance > ou equal to 50ml/mn calculated using Modification of Diet in
Renal Disease (MDRD) formula

- hematologic function : absolute neutrophil count > 1.5 x 10^9/l, platelets > 100 x
10^9/l, hemoglobin > 9,5 g/dl

- liver function : total bilirubin inferior to 1,25 x Upper limit of normal (ULN),
SGOT/SGPT inferior to 5 x ULN, PAL inferior to 5 x ULN

- PS < 2

The disease:

- histologically proven head and neck squamous cell carcinomas

- recurrent or metastatic. Visceral metastases or locoregional recurrence unsuitable
for curative locoregional treatment: unsuitable for primitive tumor surgery due to
local extension (evidently authorized for lymph nodes) and unsuitable for
radiotherapy for primitive tumor (or already performed) due to metastatic
dissemination and the absence of indication for re-irradiation of primitive tumor.

- Presence of at least one measurable lesion (defined by RECIST criteria) by CT scan or
IRM

- asymptomatic cerebral metastases authorized

General:

- signed Informed Consent Form

- affiliated to the French social security system (or a beneficiary of this system)
according to the provisions of the law of 9 August 2004

Exclusion Criteria:

- Previous systemic chemotherapy, except for chemotherapy as part of multimodal
treatment for locally advanced cancer completed more than 6 months prior to study
enrollment

- Known contraindication specific to one of study treatments (particularly cardiac for
5FU)

- Known dihydropyrimidine dehydrogenase deficiency (DPD deficiency).

- Patients considered as "unfit " (fragile) by GERICO screening method for geriatric
frailty

- Irradiation within 4 weeks prior to study enrollment.

- Nasopharyngeal, rhinopharyngeal or maxillary sinus carcinoma.

- Presence of infection (infection requiring intravenous antibiotics), including
tuberculosis and HIV infection (human immunodeficiency virus).

- Concomitant treatment with other antitumor immunotherapy or hormonal therapy.

- Other antitumor concomitant therapies.

- Prior treatment with EGFR-targeted therapy (epidermal growth factor receptor).

- Treatment with one of study drugs within 30 days prior to study enrollment.

- Presence of documented symptomatic brain or leptomeningeal metastases

- Clinically significant coronaropathy or antecedent myocardial infarction within 12
months prior to study enrollment or high-risk uncontrolled arrhythmias or
uncontrolled heart failure.

- Medically uncontrolled arterial hypertension

- Other prior or concomitant cancer, with exception for carcinoma in situ of the
uterine cervix, or for cutaneous basal cell carcinoma within 5 years prior to study
enrollment.

- Presence of medical or physiological factors susceptible to modify patient compliance
with study protocol and follow-up or Informed Consent Form signing.

- Known allergy or hypersensibility to monoclonal antibodies (bevacizumab, cetuximab),
or to other chemotherapies of the study or to their excipients