Inclusion Criteria:

1. Patients must have histologically-proven unresectable/metastatic pancreatic
adenocarcinoma.

2. Patient has one or more radiographically measurable tumor.

3. Patients may have received prior therapy with gemcitabine alone or with
fluoropyrimidines, erlotinib or radiation therapy (RT) in the past.

4. Age ≥ 18 years.

5. Patient or legal representative must have read, understood and provided written
informed consent and HIPAA authorization after full explanation of the nature of the
study.

6. ECOG performance status 0 - 2 and an expected survival of at least 3 months.

7. Acceptable hematological parameters within 2 weeks of commencing study therapy as
follows:

- Absolute neutrophil count (ANC) ≥ 1.5 x 109/L

- Platelet count ≥ 100 x 109/L

- Hemoglobin (Hgb) ≥ 9g/dl

8. Patients with adequate organ function as measured by:

A. Cardiac: American Heart Association Class I: Patients with cardiac disease but
without resulting limitation of physical activity. Ordinary physical activity does
not cause undue fatigue, palpitation, dyspnea, or anginal pain. Hepatic: Bilirubin <
2.0 mg/ and ALT and AST < 1.5x the upper limit of normal.

B. Renal: Creatinine < 1.5 mg/dl and no other chronic kidney disease.

9. Women must meet one of the following criteria:

- Post-menopausal for at least one year

- Surgically incapable of child-bearing

- Utilizing a reliable form of contraception for the duration of study
participation.

Women of child-bearing potential must have a negative serum β-HCG within 7 days of study
drug administration.

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Exclusion Criteria:

1. Previous use of nab-Paclitaxel for treatment of pancreatic cancer either as
monotherapy or combination in neo-adjuvant, adjuvant or the metastatic setting.

2. Patient has known brain metastases, unless previously treated and well-controlled for
at least 3 months (defined as clinically stable, no edema, no steroids and stable in
2 scans at least 4 weeks apart).

3. Other significant active or chronic infection.

4. History of active other malignancy excluding basal or squamous cell carcinoma of the
skin or cervical intraepithelial neoplasia.

5. Pregnant or nursing females.

6. Patient has serious medical risk factors involving any of the major organ systems, or
serious psychiatric disorders, which could compromise the patient's safety or the
study data integrity.

7. Major surgery, other than diagnostic surgery within 4 weeks of study entry. -