Inclusion Criteria:

- Clinically and histologically confirmed diagnosis of CTCL (early stage disease with
patches and/or thin plaques covering up to 10%, stage IA)

- Relapsed or refractory disease after at least one standard skin directed treatment
including corticosteroids, topical bexarotene, phototherapy

- All subjects must be 18 years of age or older

- Life expectancy ≥ 6 months, determined by the treating physician

- Signed informed consent

Exclusion Criteria:

- Patients currently receiving anticancer therapies or who have received anticancer
therapies within 4 weeks of the start of study drug (including topical or systemic
glucocorticosteroids, chemotherapy, radiation therapy, antibody based therapy, etc.)

- Prior treatment with any investigational drug within the preceding 4 weeks

- Patients receiving chronic, systemic treatment with corticosteroids or another
immunosuppressive agent.

- Female patients who are pregnant or breast feeding, or adults of reproductive
potential who are not using effective birth control methods. Adequate contraception
(oral contraceptives ("the pill"), intrauterine devices (IUDs), contraceptive
implants under the skin, or contraceptive injections, diaphragms with spermicide and
condoms with foam) must be used throughout the trial and for 8 weeks after the last
dose of study drug (women of childbearing potential must have a negative urine within
7 days prior to administration of sirolimus).

- Patients who have received prior treatment with an mTOR inhibitor (e.g., sirolimus,
temsirolimus, everolimus).

- Patients with a known hypersensitivity to sirolimus or other rapamycin (e.g.,
everolimus, temsirolimus) or to its excipient

- History of noncompliance to medical regimens

- Patients unwilling to or unable to comply with the protocol