Inclusion Criteria:

- Age 18 years or older.

- Able to give written informed consent.

- Histologically confirmed colorectal adenocarcinoma: must be either metastatic disease
or unresectable recurrent disease.

- KRAS mutation status of the primary or metastastic CRC tumor must be wild-type.

- ECOG performance status of 0-1 at study entry.

- Must have measurable disease by RECIST (ver 1.1) criteria.

- Have progressive disease based on all of the following criteria (from a-d):

(a) Previously received cetuximab-based chemotherapy as first- or second-line
treatment for metastatic or recurrent disease with, any one of the following drug
combinations: (i) Cetuximab, fluoropyrimidines and oxaliplatin; or, (ii) Cetuximab,
fluoropyrimidines and irinotecan; or (iii) Cetuximab and irinotecan. (b) Must have
achieved at least stable disease, partial or complete response to treatment stated in
'(a)' above.

(c) Experienced disease progression after more than 60 days from the last date of
administration of the treatment stated in '(a)' above.

(d) 'Disease progression' can be defined as radiological or clinical progression.

- Adequate hematologic, renal, hepatic function as defined by: absolute neutrophil
count >= 1.5 x 109/L, hemoglobin >= 9 g/L, platelets >= 100 x 109/L, calculated
creatinine clearance >=55 ml/min, total bilirubin <= 2 x the upper limit of normal
(ULN), alanine aminotransferase (ALT) <2.5 upper limit of normal or <= 5 x ULN in the
presence of liver metastases.

- Must have recovered to grade 0-1 in severity, any toxicity related to previous
cetuximab.

Exclusion Criteria:

- Disease progression during first-line or second-line treatment with cetuximab and
chemotherapy in combination.

- Patients who had prior cetuximab in BOTH first and second-line setting.

- Previous use of bevacizumab.

- Prior grade 3 to 4 hypersensitivity reaction to cetuximab.

- Clinically significant and poorly controlled medical illnesses within the last 6
months which may be exacerbated by study treatment.

- Estimated life expectancy of less than 3 months.

- Radiotherapy, surgery (excluding prior diagnostic biopsy) or any investigational drug
in the 30 days before enrollment. Radiotherapy for pain relief is allowed as long as
not targeted at an index or non-index lesion, e.g., bone metastases.

- Known brain and/or leptomeningeal metastases.

- Severe or uncontrolled cardiovascular disease (congestive heart failure NYHA III or
IV, unstable angina pectoris, history of myocardial infarction within the last twelve
months, significant arrhythmias

- Pregnancy or lactation

- Previous malignancy other than colorectal cancer in the last 5 years except basal
cell cancer of the skin or preinvasive cancer of the cervix. The non-CRC malignancy
must be in known complete remission for at least 5 years prior to enrollment.

- The presence of KRAS mutation in any of the CRC tumor tissue(s) - for example,
patients with synchronous primary CRCs with different KRAS mutation status.

- Participants with reproductive potential who are unwilling to perform effective
contraception.