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Signet Ring Cells in Esophageal and GE Junction Carcinomas Have a More Aggressive Biological Behavior

18 Years
Not Enrolling
Adenocarcinoma, Esophageal Cancer

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Trial Information

Signet Ring Cells in Esophageal and GE Junction Carcinomas Have a More Aggressive Biological Behavior

Adenocarcinoma (ADC) of the esophagus and gastroesophageal junction (GEJ) is an aggressive
neoplasm and has a poor prognosis. Surgical based treatment has been the treatment of
choice for localized esophageal adenocarcinoma.

Signet-ring cell carcinoma is a unique histologic subtype of adenocarcinoma characterized by
abundant intracellular mucin accumulation and a compressed nucleus displaced toward one
extremity of the cell (the so-called signet-ring cell (SRC)). According to the World Health
Organisation (WHO), a true signet-ring cell carcinoma (SRCca) is defined as an
adenocarcinoma in which the predominant component (more than 50% of the tumor) consists of
isolated or small groups of SRC in the stroma. If the tumor contains less than 50% of those
cells, it is generally considered as an adenocarcinoma (ADC).

Inclusion Criteria:

- Adenocarcinoma R0 resection Primary surgery

Exclusion Criteria:

- Other histology R1 or R2 resection Neoadjuvant therapy

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Retrospective

Outcome Measure:

Cancer specific 5 year survival in SRCC

Outcome Description:

Cancer specific 5 year survival classified into two groups according to WHO criteria (>50% SRC or <50% SRC)

Outcome Time Frame:

from surgery

Safety Issue:


Principal Investigator

Philippe Nafteux, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University Hospital Leuven; Dept. of Thoracic Surgery


Belgium: Federal Agency for Medicinal Products and Health Products

Study ID:




Start Date:

March 2012

Completion Date:

December 2012

Related Keywords:

  • Adenocarcinoma
  • Esophageal Cancer
  • Esophagectomy
  • Signet Ring Cells
  • Adenocarcinoma
  • Adenocarcinoma, Mucinous
  • Carcinoma
  • Esophageal Diseases
  • Esophageal Neoplasms
  • Carcinoma, Signet Ring Cell