Signet Ring Cells in Esophageal and GE Junction Carcinomas Have a More Aggressive Biological Behavior
Adenocarcinoma (ADC) of the esophagus and gastroesophageal junction (GEJ) is an aggressive
neoplasm and has a poor prognosis. Surgical based treatment has been the treatment of
choice for localized esophageal adenocarcinoma.
Signet-ring cell carcinoma is a unique histologic subtype of adenocarcinoma characterized by
abundant intracellular mucin accumulation and a compressed nucleus displaced toward one
extremity of the cell (the so-called signet-ring cell (SRC)). According to the World Health
Organisation (WHO), a true signet-ring cell carcinoma (SRCca) is defined as an
adenocarcinoma in which the predominant component (more than 50% of the tumor) consists of
isolated or small groups of SRC in the stroma. If the tumor contains less than 50% of those
cells, it is generally considered as an adenocarcinoma (ADC).
Observational
Observational Model: Cohort, Time Perspective: Retrospective
Cancer specific 5 year survival in SRCC
Cancer specific 5 year survival classified into two groups according to WHO criteria (>50% SRC or <50% SRC)
from surgery
No
Philippe Nafteux, MD
Principal Investigator
University Hospital Leuven; Dept. of Thoracic Surgery
Belgium: Federal Agency for Medicinal Products and Health Products
SRCC
NCT01824966
March 2012
December 2012
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