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Screening for Asymptomatic Portal Vein Thrombosis and Portal Hypertension in Patients With Philadelphia Negative Myeloproliferative Neoplasms


N/A
N/A
N/A
Open (Enrolling)
Both
Myeloproliferative Neoplasms (MPN), Polycythemia Vera (PV), Essential Thrombocythemia (ET), Myelofibrosis (MF)

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Trial Information

Screening for Asymptomatic Portal Vein Thrombosis and Portal Hypertension in Patients With Philadelphia Negative Myeloproliferative Neoplasms


Inclusion Criteria:



- One of the three classical Philadelphia negative myeloproliferative neoplasms
(polycythemia vera (PV), essential thrombocythemia (ET) and myelofibrosis (MF))
diagnosed according to WHO or International working group-Myelofibrosis research and
treatment (IWG-MRT) criteria

- Palpable spleen length >5 cms below the costal margin in MF (including primary MF or
post-polycythemia vera MF (PPV-MF) post-polycythemia vera ET (PPV-ET)) or palpable
spleen of any size in patients with PV or ET.

Exclusion criteria:

- Known history of portal vein thrombosis

- Known history of Budd-chairi syndrome

- Known history of oesophageal varices

- Known history of cirrhosis from any cause

Type of Study:

Interventional

Study Design:

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Screening

Outcome Measure:

Incidence of asymptomatic portal vein thrombosis (PVT) and/or portal hypertension (PHTN) in patients with Philadelphia negative myeloproliferative neoplasms (MPNs)

Outcome Time Frame:

2 years

Safety Issue:

No

Principal Investigator

Vikas Gupta, MD, FRCP

Investigator Role:

Principal Investigator

Investigator Affiliation:

University Health Network - Princess Margaret Cancer Centre

Authority:

Canada: Ethics Review Committee

Study ID:

MPN 12-01

NCT ID:

NCT01816256

Start Date:

May 2013

Completion Date:

Related Keywords:

  • Myeloproliferative Neoplasms (MPN)
  • Polycythemia Vera (PV)
  • Essential Thrombocythemia (ET)
  • Myelofibrosis (MF)
  • Primary Myelofibrosis
  • Neoplasms
  • Hypertension
  • Hypertension, Portal
  • Myeloproliferative Disorders
  • Polycythemia
  • Polycythemia Vera
  • Thrombocythemia, Essential
  • Thrombosis
  • Venous Thrombosis
  • Thrombocytosis

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