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Observational - Gene Discovery in Osteosarcoma


N/A
N/A
N/A
Open (Enrolling)
Both
Osteosarcoma

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Trial Information

Observational - Gene Discovery in Osteosarcoma


Study Subtype: Ancillary/Correlative Observational Study Model: Cohort Time Perspective:
Retrospective Biospecimen Retention: Samples With DNA Biospecimen Description: Tissue Study
Population Description: Samples from the COG Sampling Method: Non-Probability Sample

PRIMARY OBJECTIVES:

I. To use PET sequencing to analyze DNA from ten human primary osteosarcoma samples, along
with matched normal tissue where available.

OUTLINE:

Tissue samples are analyzed for translocations and deletions and analyzed using polymerase
chain reaction (PCR) or fluorescence in situ hybridization (FISH).


Inclusion Criteria:



- Samples from the COG tissue repository

Type of Study:

Interventional

Study Design:

Intervention Model: Single Group Assignment, Masking: Open Label

Outcome Measure:

Mapping and filtering of paired tags

Outcome Description:

Mapping of paired tags to reference genomes to identify aberrant pairs, caused by translocations, insertions, deletions and inversions.

Outcome Time Frame:

Up to 2 years

Safety Issue:

No

Principal Investigator

Richard Gorlick

Investigator Role:

Principal Investigator

Investigator Affiliation:

Children's Oncology Group

Authority:

United States: Institutional Review Board

Study ID:

AOST10B1

NCT ID:

NCT01807143

Start Date:

January 2010

Completion Date:

Related Keywords:

  • Osteosarcoma
  • Osteosarcoma

Name

Location

Children's Oncology GroupArcadia, California  91006-3776