Inclusion Criteria:

18~75 years Patients who were diagnosed by the histologic, cytologic diagnosis of IIIb-IV
non-small cell lung cancer patients who have acceptted combination chemotherapy based on
platinum 4 course,SD OR PR,the CR patients should accept 6 course of combination
chemotherapy.

3~8 weeks after patients complete first line chemotherapy(include radiotherapy) Ecog0-2
Expected life time longer than 3 monthes

Normal laboratory values:

- leucocyte ≥ 4×109/L

- neutrophil ≥ 1.5×109/L

- platelet ≥ 100×109/L

- Hemoglobin ≥ 10g/L

- ALT and

- AST ≤ 2.5×ULN (≤ 5×ULN if liver metastasis) Signed written informed consent

Exclusion Criteria:

- Patients have used drugs according to protocol

- Uncontrolled infection of Bacterial or virus or fungal

- Patients with other malignant tumor

- Uncontrolled brain metastases

- Female patients during their pregnant and lactation period, or patients without
contracep