Inclusion Criteria:

- biopsy-proved NPC

- N3 or T4N2 or multiple lymphnodes involved with at least one mass 4 cm or more in
maximal diameter according to 7th UICC Staging

- provide written informed consent

- Kps>70

- no dostant metastasis

- Life expectancy≥6 months

- Adequate renal function, defined as follows: Serum creatinine < 2 x institutional
upper limitof normal(ULN) within 2 weeks prior to registration or; creatinine
clearance rate (CCr) ≥ 50 ml/min within 2 weeks prior to registration determined by
24- hour collection or estimated by Cockcroft-Gault formula: CCr male = [(140 - age)
x (wt in kg)] [(Serum Cr mg/dl) x (72)] CCr female = 0.85 x (CCrmale)

- The following assessments are required within 2 weeks prior to the start of
registration: Na, K, Cl, glucose, Ca, Mg, and albumin.

Exclusion Criteria:

- Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free
for a minimum of 3 years; noninvasive cancers (For example, carcinoma in situ of the
breast, oral cavity, or cervix are all permissible) are permitted even if diagnosed
and treated < 3 years ago

- Prior radiotherapy to the region of the study cancer that would result in overlap of
radiation therapy fields

- Severe, active co-morbidity