Respiratory Muscle Strength, Functional Capacity and Subjective Outcome - Effects of Inspiratory Muscle Training After Lung Cancer Surgery, a Randomized Controlled Trial
Advances in early detection and treatment improve life expectancy after surgery for lung
cancer, but living with lung cancer is frequently associated with symptoms as dyspnoea,
decreased physical capacity and fatigue several years after treatment. Lung cancer (LC)
surgery is associated with a high incidence of postoperative pulmonary complications (PPC),
having a negative impact on recovery. Although the causes of PPC are multifactorial,
respiratory muscle (RM) dysfunction has been proposed to be associated with the development
of PPC, explained by changes in RM mechanics- and function due to surgery. There is scarcity
of literature on the impact of RM dysfunction on surgical and functional outcomes after LC
surgery.
Aims: to describe longitudinal changes in RM strength in patients undergoing lung cancer
surgery and identify associations between RM strength and functional capacity. Furthermore,
to evaluate the effect of inspiratory muscle training on the recovery of respiratory muscle
strength in high risk patients referred for LC surgery.
Target population: 88 patients referred for lung cancer surgery at the Department of
Cardiothoracic Surgery, Aalborg Universityhospital.
Design: The core of this research is a prospective longitudinal observational study (study
1); included is a randomized controlled trial, based on a subpopulation from study 1.
Statistical analysis is based on mixed linear regression models and ANOVA. For the RCT we
use the generalized estimating equivalent method for parametric and Fisher´s exact test for
nonparametric data.
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention
Change in inspiratory muscle strength
Change from baseline to 5th postoperative day Change from baseline to 2 weeks after surgery
Before surgery, 5.postoperative day, 2 weeks after surgery
No
Barbara C Brocki, PT
Principal Investigator
Department of Occupational Therapy- and Physiotherapy, Aalborg Universityhospital
Denmark: Danish Dataprotection Agency
AAUH 01
NCT01793155
November 2012
July 2014
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