Inclusion Criteria:

- 18 years of age or older adult women

- Instrumentation measurable lesions with histologically confirmed advanced (recurrent
or metastatic) breast cancer

- ECOG 0-2

- Advanced breast cancer in the past, patients who did not receive chemotherapy

- Recurrence if adjuvant chemotherapy and adjuvant chemotherapy in the past for more
than 6 months until the patient

- life expectancy more than 3 months

- Agree in writing before the party to participate in a clinical trial to patients

Exclusion Criteria:

- immunohistochemical staining 3 + or FISH positive anti-HER 2 therapy patients

- Severe infections requiring antibiotic therapy

- Clinically significant heart disease

- Pregnant or lactating woman

- Uncontrolled symptoms in the central nervous system (CNS) metastases

- Patients diagnosed with malignant tumors of other organs