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A Comparison of Overall Survival Post-CyberKnife Radiosurgery Treatment of Patients With 1-3 Versus 4 or More Brain Metastases


Phase 1
21 Years
95 Years
Not Enrolling
Both
Brain and Nervous System

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Trial Information

A Comparison of Overall Survival Post-CyberKnife Radiosurgery Treatment of Patients With 1-3 Versus 4 or More Brain Metastases


This is registry-based cohort study of patients with brain metastases treated at Stanford
University Medical Center (SUMC) with CyberKnife radiosurgery (CK RS). It has two
components: (1) a retrospective follow-up of patients treated since 2006, and (2) the
accrual of a new cohort of patients treated over a 5-year period from January 15, 2013 to
December 31, 2017 and followed for at least one year thereafter. The primary aim of this
study is to estimate the effect of the number of brain tumor metastases on survival after
adjusting for known risk factors for mortality.


Inclusion Criteria:



1. the presence of a tumor metastasis or tumor metastases to the brain as manifested by
the neurological examination and visibility of the metastatic lesion(s) on MRI and CT
scans

2. a Karnofsky performance status (KPS) score of greater than or equal to 60.

Exclusion Criteria:

The exclusion criteria are the converse of the above, i.e. patients without a brain tumor
metastasis or brain tumor metastases or a KPS of less than 60.

Type of Study:

Observational

Study Design:

Observational Model: Cohort

Outcome Measure:

Overall survival

Outcome Time Frame:

until death or the end of follow-up, whichever comes first.

Safety Issue:

No

Principal Investigator

Steven Chang

Investigator Role:

Principal Investigator

Investigator Affiliation:

Stanford University

Authority:

United States: Institutional Review Board

Study ID:

BRN0022

NCT ID:

NCT01778764

Start Date:

January 2013

Completion Date:

Related Keywords:

  • Brain and Nervous System
  • Neoplasm Metastasis

Name

Location

Stanford University Cancer InstituteStanford, California  94305