A Comparison of Overall Survival Post-CyberKnife Radiosurgery Treatment of Patients With 1-3 Versus 4 or More Brain Metastases
21 Years
95 Years
Both
Brain and Nervous System
Trial Information
A Comparison of Overall Survival Post-CyberKnife Radiosurgery Treatment of Patients With 1-3 Versus 4 or More Brain Metastases
This is registry-based cohort study of patients with brain metastases treated at Stanford
University Medical Center (SUMC) with CyberKnife radiosurgery (CK RS). It has two
components: (1) a retrospective follow-up of patients treated since 2006, and (2) the
accrual of a new cohort of patients treated over a 5-year period from January 15, 2013 to
December 31, 2017 and followed for at least one year thereafter. The primary aim of this
study is to estimate the effect of the number of brain tumor metastases on survival after
adjusting for known risk factors for mortality.
Inclusion Criteria:
1. the presence of a tumor metastasis or tumor metastases to the brain as manifested by
the neurological examination and visibility of the metastatic lesion(s) on MRI and CT
scans
2. a Karnofsky performance status (KPS) score of greater than or equal to 60.
Exclusion Criteria:
The exclusion criteria are the converse of the above, i.e. patients without a brain tumor
metastasis or brain tumor metastases or a KPS of less than 60.
Type of Study:
Observational
Study Design:
Observational Model: Cohort
Outcome Measure:
Overall survival
Outcome Time Frame:
until death or the end of follow-up, whichever comes first.
Safety Issue:
No
Principal Investigator
Steven Chang
Investigator Role:
Principal Investigator
Investigator Affiliation:
Stanford University
Authority:
United States: Institutional Review Board
Study ID:
BRN0022
NCT ID:
NCT01778764
Start Date:
January 2013
Completion Date:
Related Keywords:
- Brain and Nervous System
- Neoplasm Metastasis
Name | Location |
|---|---|
| Stanford University Cancer Institute | Stanford, California 94305 |
