Inclusion Criteria:

- Patients with metastatic breast cancer initiated on first-line treatment with Avastin
in combination with paclitaxel according to the current Hungarian summary of Product
Characteristics

- Patients with metastatic breast cancer initiated within 6 months before the start of
the study on treatment with Avastin according to the current Hungarian Summary of
Product Characteristics

Exclusion Criteria:

Contraindications for Avastin according to the current Hungarian Summary of Product
Characteristics:

- Hypersensitivity to active ingredient of Avastin or to any excipients

- Hypersensitivity to products produced in Chinese hamster cells or to other
recombinant or humanized antibodies

- Pregnancy

- Untreated central nervous system metastases