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A Feasibility Study Of Developing Murine Primary Xenografts From Biopsies Of Liver Metastases In Patients With Advanced Pancreatic Cancer


N/A
18 Years
N/A
Not Enrolling
Both
Pancreatic Cancer, Liver Metastases, Tumor Tissue Biopsy, Blood Samples

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Trial Information

A Feasibility Study Of Developing Murine Primary Xenografts From Biopsies Of Liver Metastases In Patients With Advanced Pancreatic Cancer


This study might bring a better understanding of the metastatic pancreatic cancer and
evaluate the differences between the metastatic and the primary pancreatic cancer (the type
that does not have metastasis).


Inclusion Criteria:



- Minimum age of 18 years old

- Pancreatic cancer with liver metastasis

- No contraindication to image-guided biopsy of liver metastasis, including
uncontrolled bleeding diathesis, uncontrolled malignant pain, inability to lie supine
etc) and no significant hepatic dysfunction.

- Provide written informed consent

- ECOG 0,1 or 2

Exclusion Criteria:

- Inability to lie supine for more than 30 minutes

- ECOG 3 or more

- Serious medical risk factors involving any of the major organ systems or including
uncontrolled bleeding diathesis, uncontrolled malignant pain, inability to lie supine
etc) and no significant hepatic dysfunction.

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Number of patients with adverse events due to biopsies

Outcome Time Frame:

2 years

Safety Issue:

Yes

Principal Investigator

Moore Malcolm, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

Princess Margaret Cancer Centre

Authority:

Canada: Ethics Review Committee

Study ID:

XENO-METPANC

NCT ID:

NCT01774643

Start Date:

January 2013

Completion Date:

June 2015

Related Keywords:

  • Pancreatic Cancer
  • Liver Metastases
  • Tumor Tissue Biopsy
  • Blood Samples
  • Pancreatic cancer
  • Liver metastases
  • Tumor tissue biopsy
  • Blood samples
  • Xenografts
  • Murine
  • Genomic profiling
  • Circulating biomarkers
  • Neoplasm Metastasis
  • Neoplasms, Second Primary
  • Pancreatic Neoplasms
  • Liver Neoplasms

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