Inclusion Criteria:

- Signed Informed Consent Form

- Age≥18 years

- Histologically or cytologically documented, incurable, locally advanced, or
metastatic solid malignancy that has progressed on, or failed to respond to, at least
one prior systemic therapy

- Evaluable or measurable disease per Response Evaluation Criteria in Solid
Tumors(RECIST)

- Eastern Cooperative Oncology Group (ECOG) performance status of 0, or 1

- Male or female patients of child-producing potential must agree to use double barrier
contraception, condoms, sponge, foams, jellies, diaphragm or intrauterine device
(IUD), contraceptives (oral or parenteral), Implanon, injectables or other avoidance
of pregnancy measures during the study and for 90 days after the last day of
treatment

- In the dose expansion stage, the patient's informed consent to providing fresh biopsy
tumor sample at baseline and day 7 should be obtained. Patients with gastric cancer ,
NSCLC, colorectal cancer, breast cancer and hepatocellular carcinoma(HCC) are
preferred to be enrolled into the dose expansion cohort.

Exclusion Criteria:

• Inadequate hematologic and organ function, defined by the following (hematologic
parameters must be assessed ≥14 days after a prior treatment, if any):

- Absolute neutrophil count ＜1500 cells/L

- Hemoglobin ＜9 g/dL

- Total bilirubin ＞1.5 × the upper limit of normal （ULN） with the following exception:
Patients with known Gilbert disease who have

serum bilirubin level ≤3× the upper limit of normal（ULN） and normal AST/ALT may be
enrolled.

- Aspartate aminotransferase （AST） and/or Alanine transaminase（ALT） ＞2.5 × the upper
limit of normal（ULN） with the following exception: Patients with documented liver
metastases may have AST and/or ALT levels ≤5 ×the upper limit of normal（ULN）.

- Serum creatinine ＞1.5 × the upper limit of normal (ULN) with the following exception:
A creatinine clearance of ≥50 mL/min based on a documented 24-hour urine collection.

- International normalized ratio (INR)＞1.5× the ULN or activated partial thromboplastin
time (aPTT)＞1.5×the ULN

- The INR applies only to patients who do not receive therapeutic anti-coagulation.

• Any anti-cancer therapy, including chemotherapy, hormonal therapy, biologic
therapy, radiotherapy, or herbal therapy within 4 weeks prior to initiation of study
treatment with the following exceptions:

- Hormonal therapy with gonadotropin-releasing hormone (GnRH) agonists for prostate
cancer

- Hormone-replacement therapy or oral contraceptives

- Palliative radiation to bone metastases ＞ 2 weeks prior to Day 1

- Herbal therapy ＞1 week prior to Day 1

- Adverse events from prior anti-cancer therapy that have not resolved to Grade ≤
1, except for alopecia

- Clinical significant active infection

- Known clinically significant history of liver disease, including viral or other
hepatitis, current alcohol abuse, or cirrhosis

- Known human immunodeficiency virus infection

- Pregnant (positive pregnancy test) or lactating women

- New York Heart Association (NYHA) Class II or greater congestive heart failure

- History of myocardial infarction or unstable angina within 6 months prior to Day
1

- History of stroke or transient ischemic attack within 6 months prior to Day 1

- Active or untreated brain metastasis

- Inability to take oral medication, prior surgical procedures affecting
absorption, or active peptic ulcer disease

- Inability to comply with study and follow-up procedures

- Any other diseases, metabolic dysfunction, physical examination finding, or
clinical laboratory finding that, in the investigator's opinion, gives
reasonable suspicion of a disease or condition that contraindicates the use of
an investigational drug or that may affect the interpretation of the results or
renders the patient at high risk from treatment complications.