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HCG Priming for Thin Endometrium in IVF

Phase 4
30 Years
50 Years
Open (Enrolling)
Endometrial Thickness, Pregnancy Outcome

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Trial Information

HCG Priming for Thin Endometrium in IVF

In this pilot study subjects with repeatedly resistant thin endometrium, less than 6mm, will
be recruited. The investigators sought to investigate the possible role of adding low dose
HCG in the follicular phase, on the endometrial growth and development. The investigators
constructed this hypothesis based on the fact that LH/HCG (luteinizing hormone/human
chorionic gonadotropin) receptor is present in endometrium and therefore a positive
interaction could be anticipated when HCG is administered in the proliferative phase of
endometrial growth. Furthermore, in a previous study, where human menopausal gonadotropin
(hMG) -well known that renders its luteinizing hormone (LH) capacity due to low dose HCG
contain- was compared to recombinant-follicular stimulating hormone (rec-FSH) during ovarian
stimulation, endometrium was more likely to be iso-echogenic and hypo-echogenic in the hMG
group, also anticipating a possible positive role of HCG activity.

Inclusion Criteria:

- (1) Less than 6mm endometrial thickness before, (2) at least two failed implantations

Exclusion Criteria:

- Abnormal uterine cavity in Hysteroscopy

Type of Study:


Study Design:

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Endometrial thickness

Outcome Description:

measured by transvaginal ultrasound

Outcome Time Frame:

14 days after estrogen treatment

Safety Issue:


Principal Investigator

Papanikolaou Evangelos, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

HRG clinical director


Greece: National Organization of Medicines

Study ID:




Start Date:

January 2012

Completion Date:

January 2014

Related Keywords:

  • Endometrial Thickness
  • Pregnancy Outcome
  • endometrium
  • thickness
  • pregnancy
  • HCG
  • frozen cycles
  • Adenoma