Inclusion Criteria:

- Histological confirmation of non-clear cell renal cancer (including chromophilic
[papillary], chromophobic, oncocytic, sarcomatoid, collecting duct [Bellini's duct])
or medullary renal cell carcinoma

- Up to one prior treatment for metastatic non clear cell carcinoma is allowed prior to
registration as long as the agent used to treat was not pazopanib

- Measurable or non-measurable metastatic disease

- Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1 or 2

- Absolute neutrophil count (ANC) >= 1500

- Platelets (PLT) >= 100,000

- Hemoglobin (HgB) > 9.0 g/dL; NOTE: Subjects may not have had a transfusion within 7
days of registration)

- Total bilirubin < 1.5 x upper limit of normal (ULN)

- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 X ULN;
NOTE: Concomitant elevations in bilirubin and ALT/AST above 1.0 x ULN is not
permitted

- Urine protein to creatinine ratio (UPC) < 1; NOTE: If UPC >= 1, then a 24-hour urine
protein must be assessed; subjects must have a 24-hour urine protein value < 1 g to
be eligible

- Prothrombin time (PT) or international normalized ratio (INR) =< 1.2 X ULN; NOTE:
Subjects receiving anticoagulant therapy are eligible if their INR is stable and
within the recommended range for the desired level of anticoagulation

- Calculated creatinine clearance must be >= 45 ml/min using the Cockcroft-Gault
formula

- A female is eligible to enter and participate in this study if she is of:

- Non-childbearing potential (i.e., physiologically incapable of becoming
pregnant), including any female who has had:

- A hysterectomy

- A bilateral oophorectomy (ovariectomy)

- A bilateral tubal ligation

- Is post-menopausal

- Subjects not using hormone replacement therapy (HRT) must have experienced
total cessation of menses for >= 1 year and be greater than 45 years in
age, OR, in questionable cases, have a follicle stimulating hormone (FSH)
value > 40 mIU/mL and an estradiol value < 40 pg/mL (< 140 pmol/L)

- Subjects using HRT must have experienced total cessation of menses for >= 1
year and be greater than 45 years of age OR have had documented evidence of
menopause based on FSH and estradiol concentrations prior to initiation of
HRT

- Childbearing potential, including any female who has had a negative serum
pregnancy test, =< 7 days prior to registration

- Agrees to use adequate contraception; acceptable contraceptive methods, when
used consistently and in accordance with both the product label and the
instructions of the physician, are as follows:

- Complete abstinence from sexual intercourse for 14 days before exposure to
investigational product, through the dosing period, and for at least 21
days after the last dose of investigational product

- Oral contraceptive, either combined or progestogen alone

- Intrauterine device (IUD) or intrauterine system (IUS) with a documented
failure rate of less than 1% per year

- Male partner sterilization (vasectomy with documentation of azoospermia)
prior to the female subject's entry into the study, and this male is the
sole partner for that subject

- Double barrier method: condom and an occlusive cap (diaphragm or
cervical/vault caps) with a vaginal spermicidal agent
(foam/gel/film/cream/suppository)

- Subjects must provide written informed consent prior to performance of study-specific
procedures or assessments, and must be willing to comply with treatment and
follow-up; procedures conducted as part of the subject's routine clinical management
(e.g., blood count, imaging study) and obtained prior to signing of informed consent
may be utilized for screening or baseline purposes provided these procedures are
conducted as specified in the protocol

- Willing to return to Mayo Clinic enrolling institution for follow-up

- Willing to provide, blood, tissue and urine samples for mandatory future unspecified
correlative research purposes

Exclusion Criteria:

- Any of the following because this study involves an investigational agent whose
genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are
unknown:

- Nursing women

- Pregnant women

- Men or women of childbearing potential who are unwilling to employ adequate
contraception

- Co-morbid systemic illnesses or other severe concurrent disease which, in the
judgment of the investigator, would make the patient inappropriate for entry into
this study or interfere significantly with the proper assessment of safety and
toxicity of the prescribed regimens

- Immunocompromised patients (other than that related to the use of corticosteroids)
including patients known to be human immunodeficiency virus (HIV) positive

- Prior history of receiving pazopanib treatments

- Uncontrolled intercurrent illness including, but not limited to:

- Ongoing or active infection

- Symptomatic anemia, uncontrolled hypertension (defined as systolic blood
pressure [SBP] of >= 140 mmHg or diastolic blood pressure [DBP] of >= 90mmHg)

- Symptomatic congestive heart failure as defined by the New York Heart
Association (NYHA); does not exclude class III congestive heart failure (CHF)

- Previously treated with therapies that are known to negatively impact cardiac
function (e.g. prior treatment with anthracyclines)

- Unstable angina pectoris

- Cardiac arrhythmia

- Evidence of active bleeding or bleeding diathesis

- Psychiatric illness/social situations that would limit compliance with study
requirements

- Or any other serious uncontrolled medical disorders in the opinion of the
investigator

- History of cerebrovascular accident including transient ischemic attack (TIA),
myocardial infarction, pulmonary embolism or untreated deep venous thrombosis (DVT),
coronary artery bypass graft surgery within 6 months prior to registration; Note:
Subjects with recent DVT who have been treated with therapeutic anti-coagulating
agents for at least 6 weeks are eligible

- Receiving any other investigational agent which would be considered as a treatment
for the primary neoplasm

- Other active malignancy =< 5 years prior to registration; EXCEPTIONS: Non-melanotic
skin cancer or carcinoma-in-situ of the cervix; NOTE: If there is a history or prior
malignancy, they must not be receiving other specific treatment for their cancer

- History or clinical evidence of central nervous system (CNS) metastases or
leptomeningeal carcinomatosis, except for individuals who have previously-treated CNS
metastases, are asymptomatic, and have had no requirement for steroids or
anti-seizure medication for 6 months prior to first dose of study drug; screening
with CNS imaging studies (computed tomography [CT] or magnetic resonance imaging
[MRI]) is required only if clinically indicated or if the subject has a history of
CNS metastases

- Clinically significant gastrointestinal abnormalities that may increase the risk for
gastrointestinal bleeding including, but not limited to:

- Active peptic ulcer disease

- Known intraluminal metastatic lesion/s with risk of bleeding

- Inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease), or other
gastrointestinal conditions with increased risk of perforation

- History of abdominal fistula, gastrointestinal perforation, or intra-abdominal
abscess =< 28 days prior to registration

- Clinically significant gastrointestinal abnormalities that may affect absorption
of investigational product including, but not limited to:

- Malabsorption syndrome

- Major resection of the stomach or small bowel

- Corrected QT interval (QTc) > 480 msecs using Bazett's formula

- Receiving any medications or substances with risk of torsades de pointes; Note:
medications or substances on the list "Drugs with Risk of Torsades de Pointes" are
prohibited; medications or substances on the list "Drugs with Possible or Conditional
Risk of Torsades de Pointes" may be used while on study with extreme caution and
careful monitoring

- Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels
and/or hemoptysis in excess of 2.5 mL (or one half teaspoon) =< 8 weeks of
registration

- Treatment with any of the following anti-cancer therapies: radiation therapy, surgery
or tumor embolization, chemotherapy, immunotherapy, biologic therapy, investigational
therapy or hormonal therapy =< 14 days prior to registration

- Prior autologous or allogeneic organ or tissue transplantation

- Elective or planned major surgery to be performed during the course of the trial

- Receiving any medications or substances that are strong or moderate inhibitors of
cytochrome P450 3A4 (CYP3A4); use of the strong or moderate inhibitors are prohibited
=< 7 days prior to registration

- Receiving any medications or substances that are inducers of CYP3A4; use of inducers
are prohibited =< 7 days prior to registration