Inclusion Criteria:

- Provision of signed, written and dated informed consent prior to any study specific
procedures

- Male or female, aged 18 years or older

- Histological or cytological confirmation of locally advanced or metastatic NSCLC
(IIIB-IV)

- Adequate tumour sample available for assessment of KRAS mutation status (via an AZ
approved laboratory or locally laboratory) and additional tumour biomarkers

- Failure of 1st line anti-cancer therapy due to radiological documentation of disease
progression in advanced disease or subsequent relapse of disease following 1st line
therapy

Exclusion Criteria:

- Mixed small cell and non-small cell lung cancer histology

- Received >1 prior anti-cancer drug regimen for advanced or metastatic NSCLC. Patients
who develop disease progression while on switch maintenance therapy (maintenance
using an agent not in the first-line regimen) will not be eligible.

- Any systemic anti-cancer therapy within 4 weeks prior to starting study treatment (6
weeks for nitrosoureas, mitomycin, and suramin) or any anti-cancer therapy which has
not been cleared from the body by the time of starting study treatment.

- Prior treatment with a MEK (Mitogen-Activated Protein Kinase) inhibitor or any
docetaxel-containing regimen (prior treatment with paclitaxel is acceptable)

- The last radiation therapy within 4 weeks prior to starting study treatment, or
limited field of radiation for palliation within 7 days of the first dose of study
treatment.