Patient Derived Breast Cancer Xenografts
- Histologic documentation of invasive breast cancer by core needle or incisional
- Cytologic documentation of metastatic disease within a body cavity, for subjects
having therapeutic removal of pleural or ascitic fluid.
- Intent to perform surgical resection of the primary tumor, or therapeutic removal of
pleural or ascitic fluid.
- Women > age 18.
- For subjects having a surgical resection of the primary tumor, the tumor must have a
clinical size of 1 cm or greater, and must not have a lobular histology on the
- Ability to give signed informed consent
Type of Study:
Observational Model: Case-Only, Time Perspective: Prospective
Thirty-five patients with breast cancer will be recruited. We anticipate that 10-30% will have successful engraftment of tumor tissue. The achievement of five successful xenografts would justify additional study.
Outcome Time Frame:
Gary Schwartz, MD
Dartmouth-Hitchcock Medical Center
United States: Institutional Review Board
- Metastatic Breast Cancer
- Breast Cancer
- Breast Neoplasms
|Dartmouth Hitchcock Medical Center||Lebanon, New Hampshire 03756|