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An Open-label,Multicenter Randomised Study of CTOP/ITE/MTX Compared With CHOP as the First-line Therapy for the New Diagnosed Young Patients With T Cell Non-hodgkin Lymphoma


Phase 4
18 Years
65 Years
Open (Enrolling)
Both
ALK-negative Anaplastic Large Cell Lymphoma, Peripherial T Cell Lymphoma,Not Otherwise Specified, Angioimmunoblastic T Cell Lymphoma, Enteropathy Associated T Cell Lymphoma, Hepatosplenic T Cell Lymphoma, Subcutaneous Panniculitis Like T Cell Lymphoma

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Trial Information

An Open-label,Multicenter Randomised Study of CTOP/ITE/MTX Compared With CHOP as the First-line Therapy for the New Diagnosed Young Patients With T Cell Non-hodgkin Lymphoma


Inclusion Criteria:



- pathologic verified mature T cell lymphoma,including ALK-negative anaplastic large
cell lymphoma,peripherial T cell lymphoma-non specific type,angioimmunoblastic T cell
lymphoma,enteropathy associated T cell lymphoma and hepatosplenic T cell lymphoma

- SGOT/SGPT no more than 2 times of UNL

- serum creatinine no more than 1.5 times of UNL

- signed informed consent

Exclusion Criteria:

- woman in pregnancy or lactation

- allergic to any intervention drug

- insuitable to the study due to severe complication

- enrolled to other study during the past 6 months

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

complete remission rate

Outcome Time Frame:

6 months

Safety Issue:

Yes

Authority:

China: Food and Drug Administration

Study ID:

CTOP

NCT ID:

NCT01746992

Start Date:

September 2012

Completion Date:

December 2018

Related Keywords:

  • ALK-negative Anaplastic Large Cell Lymphoma
  • Peripherial T Cell Lymphoma,Not Otherwise Specified
  • Angioimmunoblastic T Cell Lymphoma
  • Enteropathy Associated T Cell Lymphoma
  • Hepatosplenic T Cell Lymphoma
  • Subcutaneous Panniculitis Like T Cell Lymphoma
  • Immunoblastic Lymphadenopathy
  • Intestinal Diseases
  • Lymphoma
  • Lymphoma, Large B-Cell, Diffuse
  • Lymphoma, Non-Hodgkin
  • Panniculitis
  • Lymphoma, T-Cell
  • Lymphoma, Large-Cell, Anaplastic
  • Enteropathy-Associated T-Cell Lymphoma

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