Inclusion Criteria:

- Age >= 18 years at the time of signing the informed consent form

- Signed informed consent

- Diagnosis of AML or MDS according to WHO classification

- Planned allogeneic stem cell transplantation after reduced intensity or myeloablative
conditioning from related or unrelated donors

- At risk for iron toxicity as defined by ferritin >500 ng/ml and/or history of more
than 10 RBC transfusions prior to allo-SCT

Exclusion Criteria:

- Claustrophobia or other mental disorders making MRI imaging unbearable for the
patient

- Cardiac pacemakers, metal implants splinters or other contraindications for MRI

- More than 1 Human leukocyte antigen (HLA) allele or antigen mismatch between donor
and recipient

- Any condition, including the presence of laboratory abnormalities, which places the
subject at unacceptable risk if he/she were to participate in the study or confounds
the ability to interpret data from the study

- Patients with a history of chronic drug abuse or another illness which does not allow
the patient to assess the nature and/or possible consequences of the study

- Patients who are not likely to follow the trial protocol (lack of willingness to
cooperate)