Targeted Biopsies and the Role of Cytological Imprints for Diagnosis of Prostate Cancer
When substituting a random biopsy procedure with a few targeted biopsies, it is of outmost
importance to know immediately if the biopsy is positive or not. A recent study has
demonstrated a high sensitivity and specificity of imprint cytology of random biopsies.
The correlation between cytological imprints and histology of targeted prostate biopsies
All patients in this study are already participating in an ongoing randomized biopsy study
1. Preoperative MRI and targeted biopsies + random biopsies .
2. Random biopsies (gold standard).
Only patients with a positive MRI were included in this collateral study.
The cytological imprints (negative/positive) of each targeted biopsy is compared to the
histology (negative/positive) and Gleason score.
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
The rate of positive and negative cytological imprints, e.g presence of malignant cells or not.
The cytological imprints will be compared to the histology of targeted biopsies (defined as gold standard). Measure of agreement, sensitivity and specificity will be calculated.
Eduard Baco, MD
Oslo University Hospital
Norway:Local Regional Ethics Committee