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Analysis of Body Composition by Bioelectrical Impedance in Patients With Hepatocellular Carcinoma (HCC) Undergoing Treatment Radioablation

18 Years
65 Years
Open (Enrolling)
Liver Carcinoma

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Trial Information

Analysis of Body Composition by Bioelectrical Impedance in Patients With Hepatocellular Carcinoma (HCC) Undergoing Treatment Radioablation

There will be a prospective, longitudinal, comparative. It included 20 patients diagnosed
with hepatocellular carcinoma. As there are a finite number of active patients at the
institute, and no studies with sample size well established, has seen a sample size of 20

The duration of individual monitoring shall be one month to three visits (baseline, week 2
and week 4 after receiving the first radiofrequency ablation). Each visit will be a
nutritional assessment including anthropometry, bioelectrical impedance, biochemical tests,
Psychometric Hepatic Encephalopathy Score (PHES) and Critical Flicker Frequency (CFF).

Anthropometric measures to be taken are weight, height and arm circumference average.

Bioelectrical impedance will be using a single frequency impedance meter (425 to -50 KHz,
Range 0 to 10,000) Bioelectrical Body Composition Analyzer Quantium II RJL Systems. The team
measured the subjects' impedance, resistance, reactance and phase angle by Lean Body program
provided by the manufacturer.

Hepatic encephalopathy be evaluated by testing PHES and was measured CFF, also also be
measured ammonium, tumor necrosis factor, IL-1, IL-6, IL-10, renin angiotensin aldosterone.

Inclusion Criteria:

- Patients with a diagnosis of hepatocellular carcinoma, treatment-naive and who are
referred to the radiology department for radioablation as first therapy.

- Outpatients.

- Willingness to participate in the project.

Exclusion Criteria:

- Patients with hepato-renal diseases.

- Patients diagnosed with hepatocellular carcinoma undergoing chemoembolization
treatment, or who have received more than one session radioablation.

- Patients with depression or psychiatric illnesses

- Patients who do not agree to participate in the project.

Exclusion Criteria:

- incomplete Applied Tests

- disagreement of the person to perform any of the tests

- monitoring Breach

- Hospitalization or death after the first session radioablation.

Type of Study:


Study Design:

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

Nutritional Status

Outcome Description:

Measured with the following parameters:body weight and height (to calculate BMI), triceps skinfold and mid-arm circumference (to calculated mid-arm muscle circumference, fat mass, fat free mass total, intracellular and extracellular body water obtained by bioelectrical impedance analysis and individual vectors obtained by bioelectrical impedance vector analysis.

Outcome Time Frame:

Participants will be evaluated for a month

Safety Issue:


Principal Investigator

Aldo Torre Delgadillo, M.D. M.Sc

Investigator Role:

Principal Investigator

Investigator Affiliation:



Mexico: Secretaria de Salud

Study ID:

GAS 720-12/13-1



Start Date:

December 2012

Completion Date:

December 2013

Related Keywords:

  • Liver Carcinoma
  • Hepatocellular carcinoma
  • Radioablation
  • Carcinoma
  • Carcinoma, Hepatocellular