The Impact of Ureteral Stents on Peristalsis
Ureteral stents are commonly used in the field of urology to maintain urinary drainage and
are inserted into ureters of patients who suffer from kidney stones, urinary tract
infections or cancer. Usually the muscle cells of the ureter contract in a coordinated
fashion (peristalsis) in order to provide urinary flow from the kidney into the bladder. By
inserting a stent these contractions are disrupted, eventually resulting in a loss of
peristalsis. This phenomena is accompanied by swelling of the kidney and pain, which are
well-known negative side effects of stents. To avoid stent-related morbidity and improve
patients care this issue needs to be investigated further. A first step is to analyse the
impact of stents on peristalsis and to possibly bring these results into context with
hypothesised molecular mechanisms involved in peristalsis.
Observational
Observational Model: Cohort, Time Perspective: Prospective
Effect of stent on ureteral peristalsis in stented ureter
before and after stent insertion (approximately 30 minutes)
before and after stent insertion (approximately 30 minutes)
No
Ben Chew, MD
Principal Investigator
University of British Columbia
Canada: Health Canada
H12-03027
NCT01739738
December 2012
December 2014
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