Inclusion Criteria

Inclusion Criteria :

- Age > 18 years

- Prostate cancer proved by biopsy

- Prostate cancer not eligible for surgery referred for total or hemi HIFU ablation, OR
prostate cancer local recurrence referred for salvage HIFU ablation

- Anal and rectal normal anatomy

- Life expectancy ≥ 5 years

- Satisfactory general condition (ASA 1 to 3)

- Informed consent signed

- Affiliation to the French social security system or equivalent social security
system.

Exclusion Criteria:

- Patient treated by hormonotherapy

- Prostatic calcifications preventing HIFU ablation

- Distance between rectal mucosa and prostatic capsule ≥ 6 mm

- History of inflammatory bowel disease

- Sclerosis of the bladder neck or urethral stenosis

- Rectal fistula

- Ongoing urinary infection

- Impaired renal function (MDRD < 30mL/min/1,73 m²)

- Severe BPCO

- Acute endocarditis/ Hypercoagulation/ recent thromboembolism

- Latex or sulphur hexafluoride allergy

- Contraindication to the injection of Sonovue®

- Patient on protection of the Court, under supervision or trusteeship

- Inability to express an informed consent

- Patient already enrolled in a study that could interfere with this study.