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Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence

18 Years
Not Enrolling
Pancreatic Cancer

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Trial Information

Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence

The goal of the project is to develop a rapid in vitro screening assay for detection of
cancer biomarkers in blood. The aim is testing and optimization of nanoparticle sensors,
based on cyanine dyes that are chemically linked to Fe/Fe3O4 nanoparticles via
protease-selective consensus (cleavage) sequences. The focus is on the quantitative
determination of active cancer-specific proteases in blood via simple fluorescence
measurements. The matrix metalloproteinases, urokinase-type plasminogen activator, and
cathepsins, are up-regulated in the vast majority of progressing cancers and can, therefore,
serve as markers for cell survival/tumor progression, angiogenesis, and tissue

Inclusion Criteria:

Inclusion Criteria for Pancreatic Cancer Patients:

- Patients will either have a histologic diagnosis of pancreatic carcinoma or a
clinical picture consistent with pancreatic cancer and will be undergoing surgery or
a diagnostic procedure to confirm the diagnosis.

- Patients will have had no prior treatment or surgery

Inclusion Criteria for Healthy Subjects:

- Subjects will have no prior history of any cancer

Exclusion Criteria:

Exclusion Criteria for Pancreatic Cancer Patients

- Any prior treatment for pancreatic cancer

- Poorly controlled diabetes

Exclusion Criteria for Healthy Subjects

- Poorly controlled diabetes

Type of Study:


Study Design:

Time Perspective: Prospective

Principal Investigator

Stephen Williamson, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Kansas Medical Center Cancer Center


United States: Institutional Review Board

Study ID:




Start Date:

October 2012

Completion Date:

February 2013

Related Keywords:

  • Pancreatic Cancer
  • pancreatic cancer
  • nanoparticle
  • proteases
  • cell survival
  • tumor progression
  • angiogenesis
  • tissue remodeling/invasion
  • Pancreatic Neoplasms