Inclusion Criteria:

- Histologically proven relapsed and/or metastatic salivary gland cancer for which
potentially curative options such as surgery or radiotherapy are not indicated

- One target lesion measurable by CT-scan or MRI according to RECIST criteria

- Age + 18 years

- ECOG 0 or 1

- Adequate bone marrow, liver and renal function

- Signed written informed consent

Exclusion Criteria:

- Symptomatic metastatic brain or meningeal tumors

- History of cardiac disease such as congestive heart failure>NYHA class 2

- Active CAD

- Cardiac arrhythmias requiring anti-arrhythmic therapy or uncontrolled hypertension

- Pregnant or breast-feeding patient

- Patients with evidence or history of bleeding diathesis

- Patients undergoing renal dialysis

- Patients unable to swallow oral medication