Inclusion Criteria:

- Age ≥ 20 years at the time of signing the informed consent document

- Understand and voluntarily sign an informed consent document prior to any study
related assessments/procedures are conducted

- Able to adhere to the study visit schedule and other protocol requirements

- Previously untreated, symptomatic multiple myeloma

- Have measurable disease by protein electrophoresis analyses

- At least 65 years of age or older or, if younger than 65 years of age, not candidates
for hematopoietic stem cell transplantation

- Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2

- Must agree to comply to Lenalidomide Pregnancy Prevention Risk Management Plan

Exclusion Criteria:

- Any significant medical condition, laboratory abnormality, or psychiatric illness
that would prevent the subject from participating in the study

- Any condition including the presence of laboratory abnormalities, which places the
subject at unacceptable risk if he/she were to participate in the study

- Any condition that confounds the ability to interpret data from the study

- Previous treatment with anti-myeloma therapy

- Pregnant or lactating females

- Any of the following laboratory abnormalities:

- Absolute neutrophil count (ANC) < 1,000/microL (1.0 × 109/L)

- Untransfused platelet count (a platelet count drawn at least 7 days after the
administration of the last platelet transfusion) < 50,000 cells/microL (50 ×
109/L)

- Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3.0 × upper
limit of normal

- Renal failure requiring hemodialysis or peritoneal dialysis

- Prior history of malignancies, other than MM, unless the subject has been free of the
disease for ≥ 5 years

- Subjects who are unable or unwilling to undergo antithrombotic therapy.

- Peripheral neuropathy of ≥ grade 2 severity.

- Uncontrolled systemic fungal, bacterial, or viral infection

- Known human immunodeficiency virus (HIV) positivity (subjects who are receiving
antiretroviral therapy for HIV disease)

- Hepatitis Bs (HBs) antigen-positive, or hepatitis C virus (HCV) antibody-positive.
In case HBc antibody and/or HBs antibody is positive even if HBs antigen-negative, a
HBV DNA test should be performed and if positive the subject will be excluded.

- Primary AL (immunoglobulin light chain) amyloidosis and myeloma complicated by
amyloidosis.

- Ineligible for dexamethasone or dexamethasone is contraindicated.