Inclusion Criteria:

- Male and female between 18 and 79 years of age

- Patients diagnosed with thyroid disease who will undergo total thyroidectomy

- Naive patients to thyroid surgery

- Given written informed consent

- Childbearing potential female patients who give the consent for contraception during
the study

Exclusion Criteria:

- Pregnant or breast-feeding female patients

- Abnormal coagulation panel test

- Clinically abnormal laboratory values

- Inappropriate general health conditions

- Past or current medication history for hyperthyroidism

- Medication with aspirin (or anti-platelet) before surgery

- Current medication with anticoagulants

- Inoperable (thyroidectomy) concurrent diseases

- Concurrent diseases/conditions which will be unable to evaluate the primary and
secondary outcomes

- Participating in other interventional clinical trial