The Effect of Dexmedetomidine on Immunological Parameters of Women Undergoing Breast Cancer Surgery
Dexmedetomidine is a type of sedative used as part of anesthetic care. It is sometimes used
to help lower the amount of pain killers and other anesthetics that are given to a patient
during surgery. Researchers want to study how this drug works in cancer patients and review
the patient's chart for pain levels and medication use after surgery. Part of this
research involves studying the immune system of surgery patients.
If you agree to take part in this study, blood (about 1 tablespoon) will be drawn before you
have surgery and the morning after surgery while you are still in the hospital. This blood
will be used to learn more about how your immune system works.
After your second blood draw, your participation in this study will be over.
This is an investigational study.
Up to 20 participants will be enrolled in this study. All will take part at MD Anderson.
Observational Model: Cohort, Time Perspective: Prospective
Pre and Post Surgical Lymphocyte Counts
Lymphocyte counts determined by flow-cytometry and their function by cytotoxicity assays performed in the laboratory using samples obtained before and the morning after surgery. Patients who experience a reduction of less than 50% of their preoperative natural killer cell (NKC) activity considered as a success.
Juan P. Cata, MD
UT MD Anderson Cancer Center
United States: Food and Drug Administration
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