Inclusion Criteria:

Subjects with malignant brain tumors will be selected for photodynamic therapy if they
meet all of the following criteria.

1. Age: 6 months-18 years.

2. Location of tumor: supra- or infratentorial brain (localized, non-disseminated) with
negative CSF.

3. Tumor type: primary, or solitary metastasis, recurrent (or progressive), and
resectable.

4. MRI/CT scan characteristics:

- measurable tumor mass

- single or multiple masses accessible to light administration.

5. Subjects must have been failed by standard therapy including radiation therapy.

6. Informed consent of subject and/or the patient's legally acceptable representative.

7. Predicted life expectancy more than or equal to 8 weeks.

8. May transfuse platelets. ANC (absolute neutrophil count) more than 1,000/cmm. Coags
(PT, PTT) normal.

9. Adequate renal function defined as:

- Creatinine or radioisotope GFR more than or equal to 70 ml/min/1.73m2 or

- A serum creatinine based on age/gender within normal limits.

10. Adequate liver function defined as:

- Bilirubin (sum of conjugated + unconjugated) less than or equal to 1.5 times the
upper limit of normal (ULN) for age.

- SGPT (ALT) less than or equal to 110 U/L. For the purpose of this study, the ULN
for SGPT is 45 U/L.

- Serum albumin more than or equal to 2 g/dL.

Exclusion Criteria:

Subjects will be excluded from participation in the study on the basis of the following:

1. Life expectancy of less than 8 weeks.

2. Pregnancy.

3. Inability to consent.

4. Previous brachytherapy.

5. Previous chemotherapy within 4 weeks of enrollment.

6. Other concurrent tumor therapy.

7. Subjects with porphyria.

8. Subjects taking tetracycline, sulfonamides, phenothiazines, sulfonylureas, thiazides,
griseofulvin, fluoroquinolones, or any other potentially photosensitizing drugs.

9. Previous radiation therapy within 8 weeks of enrollment.

10. The presence of adverse events of neurologic function, photosensitivity, or
photophobia grade 4 or higher (CTCAE Version 4.02).

11. Karnofsky functional status or Lansky play scale score of less than 50.

12. Allergy to eggs, soybean oil, or safflower oil.