Inclusion Criteria

- INCLUSION CRITERIA:

Study participants will be eligible for study participation if they are/have:

- Females greater than or equal to 18 years of age. Because no dosing or adverse event
data are currently available on the use of birinapant in patients < 18 years of age,
children are excluded from this study, but will be eligible for future pediatric
trials.

- Able to understand and voluntarily sign a written informed consent, and are willing
and able to comply with the protocol requirements including the requirement for
biopsies for research purposes.

- Advanced metastatic or unresectable epithelial ovarian cancer, primary peritoneal
cancer or fallopian tube cancer that is relapsed and resistant or refractory to prior
platinum-based standard care systemic regimen. Patients who are unable to receive
further platinum, due to either allergic reaction or other medical reason, are
eligible for the protocol. There is no limitation on the amount of prior therapies
allowed.

- Patients must be at least 4 weeks from previous therapy (chemotherapy, hormonal
therapy, and radiation therapy, immunotherapy and monoclonal antibodies, alternative
therapy or investigational therapeutic agents). Patients who have had cranial
radiation therapy need to have completed it greater than or equal to 8 week s prior
to commencing on study. Patients are permitted to receive investigational imaging
agents while on study.

- Patients who have had major surgery must be fully recovered and require a recovery
period of greater than or equal to 4 weeks prior to enrolling on study.

- Histopathologic diagnosis must be confirmed in the Laboratory of Pathology (LP), NCI.

A block of the primary tumor, or access to recut slides is preferred. If this is
unavailable, a recent resection specimen of a metastatic site is required for entry. In
addition, access to archival formalin fixed paraffin embedded (FFPE) tumor blocks will be
requested to perform correlative studies. Study participants with the following histologic
epithelial ovarian cancer cell types are eligible: Serous adenocarcinoma, endometrioid
adenocarcinoma, mucinous adenocarcinoma, undifferentiated carcinoma, clear cell
adenocarcinoma, mixed epithelial carcinoma, transitional cell carcinoma, malignant
Brenner's Tumor, or adenocarcinoma not otherwise specified (N.O.S).

- Patients must have measurable disease by Response Evaluation Criteria in Solid Tumors
defined as at least one lesion that can be accurately measured in at least one
dimension (longest diameter to be recorded for non-nodal lesions and short axis for
nodal lesions) as greater than or equal to 20 mm with conventional techniques or as
greater than or equal to 10 mm with spiral CT scan, MRI, or calipers by clinical exam
and a sentinel lesion adequate for core biopsy through percutaneous biopsy. See
Section 13 for the evaluation of measurable disease.

- Life expectancy greater than 3 months.

- Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to
less than or equal to 2.

- Adequate renal function, defined as serum creatinine less than or equal to 1.5 X
upper limit of normal (ULN), or measured creatinine clearance greater than or equal
to 60 ml/min/1.73m(2).

- Adequate hepatic function, defined as AST and ALT levels less than or equal to 3 X
ULN and total bilirubin < 1.5 X ULN, unless known diagnosis of Gilbert s syndrome.

- Adequate bone marrow function, defined as absolute neutrophil (ANC) greater than or
equal to 1,500/mm(3) (greater than or equal to1.5 X10(6)/L), platelet count greater
than or equal to 75,000/mm(3) (greater than or equal to 75 X10(6)/L), and hemoglobin
greater than or equal to 10 mg/dL (transfusion to obtain hemoglobin greater than or
equal to 10 mg/dL within 24 hours prior to dosing is allowed).

- Contraception is not a consideration as these patients have all had surgical removal
of their reproductive organs. Pregnant women are excluded from this study because
birinapant may have potential for teratogenic or abortifacient effects. Because there
is an unknown but potential risk for adverse events in nursing infants secondary to
treatment of the mother with birinapant, breastfeeding should be discontinued prior
to enrollment.

EXCLUSION CRITERIA:

1. Known or suspected diagnosis of human immunodeficiency virus or chronic active
hepatitis B or C. Viral testing is not required. The reason for exclusion is
insufficient evidence demonstrating safety of administration of birinapant in
patients with HIV, hepatitis B or C due to theoretical risk of unmasking or
exacerbating these serious viral illnesses since birinapant may impair immunological
function. Data are not currently available on risk of interaction with antiretroviral
drugs. HIV-positive patients on combination antiretroviral therapy are ineligible
because of the potential for pharmacokinetic interactions with birinapant. The
potential immune suppressive effects and T-cell depletion associated with birinapant
pose an additional increased risk to these patients. Appropriate studies will be
undertaken in patients receiving combination antiretroviral therapy when indicated.

2. Symptomatic or uncontrolled brain metastases requiring current treatment (< 8 weeks
from last cranial radiation or < 4 weeks from last steroids). (Patients with abnormal
clinical exam or history will require a head CT or MRI to rule out or confirm brain
metastases).

3. Impaired cardiac function or clinically significant cardiac disease including the
following:

1. New York Heart Association grade III or IV congestive heart failure.

2. Myocardial infarction within the last 12 months prior to dosing with birinapant.

3. Subjects known to have impaired LVEF according to institutional standards must
be excluded.

4. Lack of recovery of prior adverse events to Grade less than or equal to1 severity
(National Cancer Institute Common Terminology Criteria for Adverse Events [NCI CTCAE]
v 4.03) (except alopecia) due to therapy administered prior to the initiation of
study drug dosing. Stable persistent grade 2 peripheral neuropathy may be allowed as
determined on a case-by-case basis at the discretion of the Investigator as
birinapant has not been shown to cause or exacerbate peripheral neuropathy.

5. Known allergy to any of the formulation components of birinapant including citric
acid monohydrate, sodium citrate dehydrate, and sodium chloride.

6. Any concurrent disease and/or medical condition that in the opinion of the
Investigator would prevent the subject s participation, render the subject at
excessive risk or limit the subject s compliance with the protocol s required
evaluations.

7. Patients with active infection will not be eligible, but may become eligible once
infection has resolved and they are at least 7 days from completion of antibiotics.

8. Another previous or current malignancy within the last 5 years, with the exception of
non-melanoma skin cancer, cervical carcinoma in situ curatively treated, ductal or
lobular carcinoma in situ curatively treated and without ongoing therapeutic
intervention. Patients with BRCA 1 or 2 mutation, who have had a previous diagnosis
of breast cancer are eligible if the breast cancer was diagnosed 5 years previously
and distant or local recurrence of breast cancer has been outruled.

9. Concomitant chronic (daily or almost daily for greater than or equal to1 month prior)
use of steroids or NSAIDS. Intermittent use of steroids as pre-medications is
allowed. Based on research to date the tumor and tumor microenvironment production of
TNF alpha could promote anti-tumor activity. Theoretically, anti-inflammatories could
blunt local production, limiting this possibly positive cofactor.

10. No concomitant use of complementary or alternative medication or other agents
(investigational therapeutic agents) will be allowed without approval of a PI or AI.
Every effort will be made to maximize patient safety and minimize changes in chronic
medications.

11. Patients with a recent history (within last 5 years) of autoimmune disease or
inflammatory diseases will be excluded, for example, active rheumatoid
arthritis,active inflammatory bowel disease or any chronic inflammatory conditions
because birinapant synergizes with TNF in vitro.

INCLUSION OF MINORITIES:

Women from all racial/ethnic groups are eligible for this study if they meet the
eligibility criteria.

To date, there is no information that suggests that differences in drug metabolism or
disease response would be expected in one group compared to another. Efforts will be made
to extend accrual to a representative population, but in this preliminary study, a balance
must be struck between patient safety considerations and limitations on the number of
individuals exposed to potentially toxic and/or ineffective treatments on the one hand and
the need to explore ethnic aspects of clinical research on the other hand. If differences
in outcome that correlate to ethnic identity are noted, accrual may be expanded or a
follow-up study may be written to investigate those differences more fully. This study
will be recruited through internal referral, our local physician referral base, and
through Cancer Hotline information.