Lymphoid Malignancies and Precursors: Tissue Acquisition Protocol
An estimated 79,190 people living in the United States will be diagnosed with lymphoma in
2012, including 9,060 cases of HL, 70,130 cases of non-Hodgkin's lymphoma (NHL) and multiple
cases of adult T-cell leukemia/lymphoma. Laboratory investigations conducted in the
Metabolism Branch, including analysis of cellular, molecular, genetic and genomic biology
are attempting to develop new prognostic and diagnostic models, therapeutic agents and novel
treatment approaches for lymphoid malignancies and premalignant conditions.
This biology protocol is designed to allow sample acquisition for use in the study of
lymphoid malignancies and malignancy precursors, including but not limited to B and T cell
malignancies, such as diffuse large B-cell lymphoma (DLBCL), Hodgkin's lymphoma (HL),
multiple myeloma (MM), lymphomatoid granulomatosis (LYG) and adult T-cell leukemia/lymphoma
(ATL). A variety of laboratory investigations will be conducted on blood, tumor, bone
marrow, urine, abnormal fluid and normal tissue, including analysis of cellular, molecular,
genetic and genomic biology in the support of NIH translational trials to develop new
therapeutic agents and novel treatment approaches as well as new prognostic and diagnostic
Adult patients with confirmed pathological diagnosis of lymphoid malignancy or lymphoid
precursor, including B-cell and T-cell lymphomas: including but not limited to diffuse large
B-cell lymphoma (DLBCL), Hodgkin's lymphoma (HL), multiple myeloma (MM), lymphomatoid
granulomatosis (LYG) and adult T-cell leukemia/lymphoma (ATL).
The purpose of this study is to examine, in an exploratory fashion, a variety of biologic
assays relevant to the investigation of lymphoid malignancies.
It is anticipated that up to 60 consented subjects, 50 at the NCI site, 10 at the UWI site,
will be studied each year. Thus, an accrual ceiling of 600 consented subjects is planned
over 10 years.
Time Perspective: Prospective
Wyndham H Wilson, M.D.
National Cancer Institute (NCI)
United States: Federal Government
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