Trial Information

Phase III Trail of Internal Mammary Sentinel Lymph Node Biopsy in Early Breast Cancer Patients With Clinically Axillary Node -Positive

OBJECTIVES:

- Determine the impact of routinely performed internal mammary sentinel lymph node biopsy
on the systemic and locoregional treatments plan.

- Evaluate the metastasis rate of internal mammary sentinel lymph nodes in patients with
clinically axillary node-positive.

- Draw the learning curve of internal mammary sentinel lymph node biopsy.

OUTLINE:

3~18 hours before surgery, under ultrasonographic guidance, 0.5~1.0 mCi 99mTc-labeled sulfur
colloid in sterile saline (total volume 0.2~2.0 mL) is injected intraparenchymally into 2
quadrants of breast. Subsequently, lymphoscintigraphy is performed 0.5~1.0 hour before
surgery. internal mammary sentinel lymph node biopsy is performed during the surgery and the
internal mammary sentinel lymph nodes were sent to histologic examination.