Inclusion Criteria:

- Patients must have HIGH GRADE upper tract urothelial carcinoma

- Patients must be considered to be a candidate for surgery with curative intent
(nephroureterectomy or distal ureterectomy) with lymph node dissection by the
treating urologist at baseline within 42 days prior to registration.

- Patients must be able to care for themselves and must be up and about more than 50%
of waking hours

- All patients must be evaluated by a medical oncologist at baseline within 42 days
prior to registration. Patients must be considered to be a candidate for
cisplatin-based neoadjuvant chemotherapy by a medical oncologist at baseline and must
have adequate kidney function and any pre-existing peripheral neuropathy must be
moderate to mild.

- Prior uro-oncologic history:

- History of or active non-invasive carcinoma or carcinoma in situ of the bladder
or upper tract is allowed.

- Patients may have received prior intravesical chemotherapy or immunotherapy such
as BCG.

- Prior neoadjuvant chemotherapy for bladder cancer or invasive contralateral
upper tract cancer is allowed.

- Prior adjuvant chemotherapy for bladder cancer or invasive contralateral upper
tract cancer is allowed but must have been completed ≥2 years prior to study
registration.

- Patients must have adequate organ and bone marrow function as determined by screening
tests

- Patients must have recovered from any reversible toxicities of prior procedure or
surgery

- Patients must be 18 years or older on date of registration

- All patients must be informed of the investigational nature of this study and must
sign an informed consent document

Exclusion Criteria:

- Patients must have no evidence of regional lymphadenopathy or distant metastasis on
imaging.

- No history of invasive or node positive or metastatic bladder cancer or invasive
contralateral upper tract cancer within 2 years prior to registration.

- Patients with one kidney are not eligible

- Patients may not be enrolled in another interventional clinical trial at the time of
registration.

- No prior non-urothelial malignancy is allowed, except for cancer from which the
patient has been disease free for at least 1 year at the discretion of the treating
oncologist. History of adequately treated (at the discretion of the treating
oncologist) basal cell or squamous cell skin cancer or in situ cervical cancers is
allowed.

- Pregnant or lactating women are not eligible. Women/men of reproductive potential
must agree to use an effective contraceptive method. Women with reproductive
potential must have a negative pregnancy test within 14 days prior to registration.

- Patients must not have any other medical condition(s) that make(s) their
participation in the study unadvisable in the opinion of the treating oncologist.