Inclusion Criteria:

1. Karnofsky ≥ 70

2. Provision of informed consent

3. Pathological confirmation of breast cancer and exclusion of other metastases.

4. Pathological confirmation of triple negative or Her-2 positive or with more than 4
axillary lymph node metastasis

5. The patients have finished the chemotherapy of Anthracycline and/or Taxane.And it's
no more than 28 days from accepting the last chemotherapy.

6. Laboratory criteria:

PLT ≥ 100*109/L WBC ≥ 4000/mm3 HGB ≥ 10g/dl GOT,GPT,ALP ≤ 2*ULN TBIL,DBIL,CCr ≤ 1.5*ULN

Exclusion Criteria:

1. Pregnant or lactation woman

2. Bilateral breast cancer, inflammatory breast cancer or carcinoma in situ

3. Accepted neoadjuvant treatment including chemotherapy, radiotherapy and endocrine
therapy

4. History of organ transplantation

5. With mental disease

6. With severe infection or active gastrointestinal ulcers

7. With severe liver disease (such as cirrhosis), kidney disease, respiratory disease or
diabetes

8. Disease-free period of other malignant tumor is less than 5 years(except cured basal
cell skin cancer and cervical carcinoma in situ)

9. With heart disease

10. Experimental drug allergy